Andariel
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Ancient Horadric texts record that Andariel and the other Lesser Evils once overthrew the three Prime Evils - Diablo, Mephisto and Baal - banishing them from Hell to our world. With this betrayal weighing against her, Andariel's presence in Sanctuary can only mean that the forces of Hell are once again aligned behind Diablo and his Brothers. While it is clear that the Maiden of Anguish is acting on behalf of Diablo to prevent anyone from following him eastward, it is also clear that she must be destroyed if the Lord of Terror is to be stopped.
Diablo II Andariel
For more information about Andariel's stats and tactics against her, please see Andariel.