[[Image:Runes.jpg|thumb|right|175px|Runes of [[Sanctuary]].]]The new '''[[Rune|Skill Rune system]]''' of [[Diablo 3]] will be vastly different than the {{iw|Rune Diablo 2 runes}}, as they will no longer be socketed into items, but instead infused into '''[[skill]]s''' directly. They also , and have a bigger impact on much greater gameplay, as it not only have a visual effect, but major enhancements to the selected skills as well.

[[Image:Runeskill.jpg|thumb|70px|right|Socket.]]During [[BlizzCon 2008]], it was possibly to try out these [[Rune|skill runes]] in action, but only with the newly announced [[Wizard]] class. Players could add an a rune to a Wizard spell and create new effects such as hitting more targets or causing damage in a greater area.   [[Energy Rune]], [[Lethality Rune]], [[Multistrike Rune]], [[Power Rune]] or a [[Striking Rune]] to a Wizard spell to create new effects such as hitting more targets or causing damage in a greater area.