Changes from this one to the most recent version aren't major, but they are visible. There were initially 1-6 hotkeys, along with right but 5 and left mouse click buttons6 could only be used for potions or scrolls. The RMB, LMB, and Tab worked the same, but were not yet labeled on the interface. The game option controls for trading, multiplayer options, and more were previously on top, as they were in Diablo II. In more recent versions they've been moved to a small rectangle on the far right.