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From Diablo Wiki
→Function
* The '''left mouse button''' (LMB) skill remains there all the time, unless/until you drag another skill down to replace it.
* The '''right mouse button''' (RMB) has two skills; you switch between them by clicking the '''Tab '''button, or by rolling the mouse wheel. These are usually the secondary skills, but ones you wish to use almost constantly.
** The visual aspect of the Tab skill was removed in mid-2011[http://diablo.incgamers.com/blog/comments/blue-offers-diablo-iii-interface-explanations] though the function was preserved at that point.
* The '''1234''' buttons cast whichever skills are mapped to those buttons, targeting the spell for where the cursor is pointing, just like a mouse click. These are generally summoning or buff skills, but can also be direct attack skills.
** You may also map potions, elixirs, or scrolls to the 1234 buttons.
